The Challenges of Adopting PLM Tools Involving Diversified Technologies in Today’s Automotive Supplier Business

In order to reduce product development (PD) costs and duration, PD cycles are being accelerated in order to reduce the time to market and satisfy the end customer needs. Another key challenge in PD today, is product diversification in the technologies used, requiring improved collaboration amongst local and dispersed multi disciple PD teams. A main stream tool that aids and support engineers in PD to collaborate and share information/knowledge is Product Lifecycle Management (PLM). This research explores the benefits and requirements of implementing a PLM system for a PD and manufacturing company within the automotive supply chain. This paper first provides a brief background of the subject area, followed by an explanation of the initial industrial investigation for the implementation of a PLM system, from which investigation the resulting conclusions and recommendations are presented as the building blocks of the implementation project

A blood RNA transcriptome signature for COVID-19.

BACKGROUND: COVID-19 is a respiratory viral infection with unique features including a more chronic course and systemic disease manifestations including multiple organ involvement; and there are differences in disease severity between ethnic groups. The immunological basis for disease has not been fully characterised. Analysis of whole-blood RNA expression may provide valuable information on disease pathogenesis. METHODS: We studied 45 patients with confirmed COVID-19 infection within 10 days from onset of illness and a control group of 19 asymptomatic healthy volunteers with no known exposure to COVID-19 in the previous 14 days. Relevant demographic and clinical information was collected and a blood sample was drawn from all participants for whole-blood RNA sequencing. We evaluated differentially-expressed genes in COVID-19 patients (log2 fold change ≥ 1 versus healthy controls; false-discovery rate  0.05). CONCLUSIONS: The whole-blood transcriptome of COVID-19 has overall similarity with other respiratory infections but there are some unique pathways that merit further exploration to determine clinical relevance. The approach to a disease score may be of value, but needs further validation in a population with a greater range of disease severity

The strenght of strong ties: how co-authorship affect productivity of academic economists

Increased specialization and extensive collaboration are common behaviours in the scientific community, as well as the evaluation of scientific research based on bibliometric indicators. This paper aims to analyse the effect of collaboration (co-authorship) on the scientific output of Italian economists. We use social network analysis to investigate the structure of co-authorship, and econometric analysis to explain the productivity of individual Italian economists, in terms of \u2018attributional\u2019 variables (such as age, gender, academic position, tenure, scientific sub-discipline, geographical location), \u2018relational\u2019 variables (such as propensity to cooperate and the stability of cooperation patterns) and \u2018positional\u2019 variables (such as betweenness and closeness centrality indexes and clustering coefficients)

TUMORI A CELLULE GERMINALI IN ETA' PEDIATRICA. RISULTATI DEL PROTOCOLLO AIEOP "TG-91".

Gli Autori riportano i risultati del Protocollo AIEOP-91 presentando igli 88 casi registrati in 15 Centro AIEOP dal gGennaio 1991 al Dicembre 19